Induced pluripotent stem cells: advances in research and application in dermatology
10.3760/cma.j.issn.0412-4030.2019.07.001
- VernacularTitle:诱导性多功能干细胞在皮肤科研究与应用的进展
- Author:
Yumei LI
1
;
Yixuan ZHANG
;
Liping LIU
Author Information
1. 江苏大学附属医院皮肤科镇江市免疫性皮肤病重点实验室
- Keywords:
Multipotent stem cells;
Regenerative medicine;
Skin diseases;
Disease models,animal;
Gene therapy;
Induced pluripotent stem cells
- From:Chinese Journal of Dermatology
2019;52(7):445-449
- CountryChina
- Language:Chinese
-
Abstract:
Induced pluripotent stem cells (iPSCs) are a kind of stem cells induced from somatic cells by reprogramming with some specific pluripotent transcription factors.Compared with traditional stem cells,iPSCs have many advantages,including a wide range of sources,the ability of totipotent differentiation,and less ethical and sourcing issues associated with embryonic stem cells which have been debated for a long time.In dermatology,iPSCs can be used to make regenerative skin,establish models of skin diseases,provide a new platform for studying the pathogenesis of skin diseases,and perform cell treatment or gene modification treatment for specific skin diseases.At present,the application value of iPSCs has been verified among animal models,and clinical trials are also under way.