25?hydroxyvitamin D, sex hormone levels and cardiovascular risk among men in northeast area of Henan province
10.3760/cma.j.issn.0578?1426.2019.09.008
- VernacularTitle:河南省东北部地区成年男性25羟维生素D水平与性激素和心血管危险因素的相关性分析
- Author:
Jiao WANG
1
;
Xiaojun MA
;
Yanling LIU
;
Yanyan ZHAO
;
Zhizhen LI
;
Feng GUO
;
Xiaokun MA
;
Lina WU
;
Weiping TENG
;
Guijun QIN
Author Information
1. 郑州大学第一附属医院内分泌代谢科
- Keywords:
25?hydroxyvitamin D;
Males;
Sex hormones;
Cardiovascular risk factors
- From:
Chinese Journal of Internal Medicine
2019;58(9):673-679
- CountryChina
- Language:Chinese
-
Abstract:
To examine associations of 25?hydroxyvitamin D [25(OH)D] concentrations with sex hormone levels and cardiovascular risk factors. Methods A total of 697 male subjects were obtained from the thyroid disorders, lodine status and diabetes: a national epidemiological survey?2014 (TIDE) research??Henan sub?center survey through multistage stratified cluster random sampling from December 2015 to March 2016. The associations between 25(OH)D and sex hormones or cardiovascular risk factors were analyzed by linear regression analyses. Results The age of the subjects was (46.6 ± 15.9) years (19?85 years). Proportions of vitamin D deficient, vitamin D intermediate and vitamin D optimal were 9.3%, 13.1% and 77.6%, respectively. More subjects with vitamin D deficient were in urban area than in rural area (13.3% vs. 5.7%, P=0.001). After fully adjusting for age, residence area, economic status, education, body mass index, waist circumference, homeostasis model assessment of insulin resistance (HOMA?IR), hypertension, diabetes, triglyceride, high?density lipoproteincholesterol, total cholesterol, low?density lipoprotein cholesterol and uric acid, linear regression analyses showed that every 25 nmol/L increase in 25(OH)D levels increased lg FT(FT=free testosterone) by 0.013ng/L (β=0.013, P=0.036), lg DHT (DHT=dihydrotestosterone) by 0.030 ng/L (β=0.030, P=0.019), and lg AD (AD=androstenedione) by 0.019 μg/L (β=0.019, P=0.008). After fully adjusting for age, residence area, economic status and education, every 25 nmol/L increase in 25(OH)D levels lowered glycosylated hemoglobin A1c (HbA1c) by 0.051% (β=-0.051, P=0.027). Conclusions Higher 25(OH)D concentrations in men were associated with higher FT, DHT, AD and lower HbA1c levels.
