Evaluation of quality of life in patients with Graves orbitopathy and its influencing factors
10.3760/cma.j.issn.0578-1426.2019.08.006
- VernacularTitle:初诊Graves眼病患者生活质量及其影响因素
- Author:
Chanyan WENG
1
;
Zhangfang LI
;
Shidi HU
;
Yaosheng LUO
;
Xiaoting FENG
;
Qiang ZHONG
;
Qing ZHANG
;
Jie SHEN
Author Information
1. 南方医科大学第三附属医院内分泌代谢科
- Keywords:
Graves orbitopathy;
Quality of life;
Graves orbitopathy guality of life questionnaire
- From:
Chinese Journal of Internal Medicine
2019;58(8):577-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate life quality of Graves orbitopathy (GO) patients using Graves orbitopathy quality-of-life questionnaire (GO-QOL) and explore the influence factors of the quality of life of GO patients.Methods This was a cross-sectional study conducted at The Third Affiliated Hospital of Southern Medical University including 145 newly diagnosed GO patients.All the patient answered the GO-QOL and underwent ophthalmic and endocrine assessments.The main outcome measures were the scores on GO-QOL 2 subscales:visual functioning and appearance.Based on the classification in the guideline of European Group on Graves Orbitopathy (EUGOGO),the patients were divided into two groups:mild and moderate to severe groups.Then the scales between these two groups were compared and influencing factors were analyzed.Finally,the floor and ceiling effects were assessed.Results The GO-QOL scores for the subscales of visual functioning and appearance were 70.91±27.83 and 61.29±26.37 respectively in 145 GO patients.Visual functioning and appearance were lower in moderate to severe group (62.71 ±28.77 and 57.52 ± 26.49,respectively) than in mild group (85.58 ± 18.77 and 68.02 ±24.99,respectively).The GO-QOL scores for the visual functioning subscale were significantly correlated with age (P =0.002),clinical active score (P =0.011) and the degree of diplopia (P =0.00,R2=0.373).The GO-QOL scores for the appearance were significantly correlated with sex (P =0.05) and thyroid-stimulating hormone levels (P =0.001,R2 =0.231).No significant ceiling or floor effects were observed for either subscale of the GO-QOL.Conclusions With the aggravation of the disease,the quality of life of GO patients is getting worse and worse.The main influencing factors of the quality of life of GO patients include age,gender,diplopia,clinical active score and thyroid-stimulating hormone levels.Close attention needs to be paid to the quality of life of GO patients.
