The influencing factors achieving target vancomycin trough level in critically ill patients
10.3760/cma.j.issn.0578-1426.2019.08.005
- VernacularTitle:重症患者万古霉素谷浓度达标情况及其影响因素分析
- Author:
Jinlong WANG
1
;
Haofei WANG
;
Mengjuan SHI
;
Jingyuan XU
;
Lili HUANG
;
Qing LI
;
Songqiao LIU
;
Yingzi HUANG
Author Information
1. 东南大学附属中大医院重症医学科
- Keywords:
Vancomycin;
Trough level;
Pharmacokinetics;
Nephrotoxicity
- From:
Chinese Journal of Internal Medicine
2019;58(8):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the rate achieving the target vancomycin trough level (VTL) and its influencing factors in critically ill patients.Methods The retrospective observational study recruited adult patients treated with intravenous vancomycin in the intensive care unit (ICU) at Zhongda Hospital from January 2015 to December 2017.Serum VTL was tested at steady state.Patients' demographics,the sites of infection,microbial culture results,the severity of illness,laboratory data and vancomycin regimen were obtained at the baseline.The rate achieving target VTL (15-20 mg/L) was analyzed based on renal function.Linear regression was performed to determine the influencing factors of VTL.Results A total of 85 patients were enrolled,among whom only 23.5％ (20/85) achieved the target VTL.In patients with normal renal function,the achieving rate was only 11.4％ (4/35),and 80.0％ (28/35) was lower than the target trough level multiple linear regression analysis showed that procalcitonin (PCT),estimated glomerular filtration rate (eGFR) and acute physiology and chronic health disease classification system Ⅱ (APACHE Ⅱ) score were independent factors associated with VTL.Conclusion Achieving target VTL in critically ill patients is not satisfactory.Further study to optimize the administration is needed to facilitate prompt attainment of target VTL.
