A randomized controlled study of peramivir, oseltamivir and placebo in patients with mild influenza
10.3760/cma.j.issn.0578-1426.2019.08.003
- VernacularTitle:帕拉米韦、奥司他韦和安慰剂治疗流行性感冒的随机对照研究
- Author:
Hongwei FAN
1
;
Yang HAN
;
Wei LIU
;
Xingwang LI
;
Lizhong LI
;
Heyun YAO
;
Yong WANG
;
Zhiqiang SU
;
Weixian YE
;
Jin HUANG
;
Weizhong LU
;
Guiwei LI
;
Hailing LI
;
Shaoyang WANG
;
Hao WU
;
Qiaofa LU
;
Guangfa ZHU
;
Shengming LIU
;
Gang CHEN
;
Wenhong ZHANG
;
Taisheng LI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院感染科 100730
- Keywords:
Influenza;
Peramivir;
Oseltamivir
- From:
Chinese Journal of Internal Medicine
2019;58(8):560-565
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To evaluate the effectiveness and safety of peramivir trihydrate in patients with influenza.Methods This was a randomized,double-blind,double-dummy,placebo and positive control,multicenter clinical trial,comparing peramivir trihydrate with oseltamivir and placebo.The inclusive criteria were 15-70 years old,onset within 48 h,positive rapid influenza antigen test,and febrile(＞38℃) accompanied with at least two associated symptoms.The severe cases complicated with chronic pulmonary and cardiac diseases,malignancies,organ transplantation,hemodialysis,uncontrolled diabetes,immunocompromised status,pregnancy and coexistence of bacterium infections were excluded.All patients were randomized 2:2:1 to receive peramivir,oseltamivir and placebo respectively.The primary endpoint was the disease duration,the secondary endpoints included time to normal axillary temperature and normal living activities,viral response,and adverse effects.Results Following informed consent,133 patients were included in this study.Four patients were exclude due to missing medical records,not fitting inclusion or exclusion criteria and poor compliance.A total of 129 patients were finally analyzed,including 49 cases,54 cases and 26 cases in peramivir group,oseltamivir group and placebo group.The median disease duration were 96 (76,120)hours,105(90,124) hours,and 124 (104,172)hours in three groups respectively(P＞0.05).The time to normal axillary temperature,normal living activities and viral response were not significantly different in three groups(P＞0.05).Conclusion The value of antiviral therapy in patients with mild influenza needs to be further determined.
