The neurological manifestations in 52 patients with primary Sj?gren′s syndrome
10.3760/cma.j.issn.0578?1426.2019.07.008
- VernacularTitle:原发性干燥综合征相关神经系统损害52例临床特征
- Author:
Yao ZHANG
1
;
Yan XU
;
Jiuliang ZHAO
;
Mengtao LI
;
Yan ZHAO
;
Xiaofeng ZENG
;
Liying CUI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科100730
- Keywords:
Sj?gren′s syndrome;
Neurological involvement;
Central nervous system injury;
Peripheral nervous system injury
- From:
Chinese Journal of Internal Medicine
2019;58(7):525-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the neurological manifestations in patients with primary Sj?gren′s syndrome (pSS). Methods A total of 68 patients were diagnosed as pSS in neurology department of Peking Union Medical College Hospital from March 2014 to February 2018, among whom sixteen cases were excluded due to modified final diagnoses of primary neurological diseases. Therefore 52 pSS patients with neurological involvement were enrolled and retrospectively analyzed. They were divided into two groups as extensive group in which both central and peripheral nervous system were involved, non?extensive group in which either central or peripheral nervous system was involved. Results Neurological manifestations were presented as primary symptoms in 98.1%(51/52) patients, while 35 had neurological involvement as their only extraglandular manifestations. Thirteen cases were in extensive group. The other 39 in non?extensive group including 22 cases with only peripheral nervous system involved and 17 cases with only single central nervous system involved. Compared to non?extensive group, the proportion of woman patients [13/13 vs.71.8% (28/39),P＝0.047], serum IgG level [17.73(11.11,22.41)g/L vs. 11.49(9.58,13.40)g/L, P＝0.017] and positive rates of oligoclonal band (OB) in cerebral spinal fluid (CSF) [7/13 vs. 22.6%(7/31), P＝0.042)] were significantly higher in extensive involvement group. Conclusions Neurological manifestations in pSS patients could be extensive, both central and peripheral nervous system might be associated. Female patients, high serum IgG level and positive OB in CSF are risk factors of extensive neurological involvement, suggesting that the immune system may be generally over?stimulated.
