The analysis of peripheral blood T lymphocyte subsets in patients with colorectal cancer : a single center cross-section study
10.3760/cma.j.issn.0578-1426.2019.06.011
- VernacularTitle:结直肠癌患者外周血T淋巴细胞亚群的研究
- Author:
Tixian XIAO
1
,
2
;
Guannan ZHANG
;
Zhifeng QIU
;
Chungen XING
;
Taisheng LI
Author Information
1. 中国医学科学院北京协和医学院北京协和医院感染内科 100730
2. 苏州大学医学部 215006
- Keywords:
Colorectal neoplasms;
Peripheral blood T-lymphocyte subsets
- From:
Chinese Journal of Internal Medicine
2019;58(6):453-455
- CountryChina
- Language:Chinese
-
Abstract:
The distribution of peripheral blood lymphocyte subsets were compared between patients with colorectal cancer and healthy controls.The number of natural killer(NK) cells and CD8+T cells and the percentage of naive CD4+T cells were all decreased significantly in patients.On the contrary,the percentages of memory CD4+T cells,HLA-DR+ CD8+ T cells and CD38+ CD8+ T cells were significantly increased.It suggests that the tumor killing effect of cytotoxic lymphocytes in peripheral blood is impaired in patients with colorectal cancer,whereas the immune response is over stimulated.
