Recognizing hyperuricemia from the viewpoint of the inflammation

VernacularTitle:高尿酸血症的现代进化与多重性作用 ——从炎症角度审视高尿酸血症
Author: Xuane ZHANG ^{1
,

2} ; Shen QU
Author Information

1. 上海市第十人民医院内分泌代谢科 200072
2. 同济大学附属杨浦医院内分泌代谢科
Keywords: Uric acid; Inflammatory; Oxidation; Antioxidant
From: Chinese Journal of Endocrinology and Metabolism 2019;35(8):718-722
CountryChina
Language:Chinese
Abstract: Uric acid is an antioxidant in the extracellular environment, while it has prooxidative effects inside the cell. It is thought that antioxidative effects of uric acid may be protective, particularly in neurological diseases. While prooxidative effects of uric acid has a leading role in the development and progress of chronic kidney disease, metabolic syndrome and cardiovascular diseases. Uric acid is more than a product of purine metabolism. The uric acid paradox indicates that uric acid may play a central role in many diseases. This article was tried to review the researches and clinic studies of hyperuricemia from the viewpoint of the inflammation in recent years.