A case of liver cirrhosis due to hypopituitarism in adolescence after nasopharyngeal carcinoma radiotherapy

VernacularTitle:儿童期鼻咽癌放疗后生长激素缺乏症合并肝硬化一例报道
Author: Lina SUN ¹ ; Wei JIANG ; Xin GAO ; Xiaoying LI ; Yuan JI ; Xinxia CHANG
Author Information

1. 复旦大学附属中山医院内分泌科
Keywords: Hypopituitarism; Growth hormone deficiency; Nonalcoholic fatty liver disease; Cirrhosis
From: Chinese Journal of Endocrinology and Metabolism 2019;35(8):715-717
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease is a metabolic stress liver injury, including simple hepatic steatosis, nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Liver fibrosis in NASH patients progressed by an average of 7 to 10 years, and the incidence of cirrhosis in NAH patients was only 0.6％to 3.0％after 10 to 20 years of follow-up. This case reports a 21-year-old man with pituitary dysfunction and cirrhosis, whose condition develops rapidly. The mechanism may be that growth hormone deficiency affects liver signaling transduction pathways to make the liver metabolism disordered, causing nonalcoholic fatty liver disease. In this report, the pathogenesis, diagnosis and treatment of this case of cirrhosis duo to hypopituitarism in adolescence are reviewed retrospectively to improve the understanding of the diagnosis and therapy of this disease.