The review of the effects of glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists on hypothalamus-pituitary-gonad axis

VernacularTitle:胰升糖素样肽1和胰升糖素样肽1受体激动剂对下丘脑-垂体-性腺轴作用的研究进展
Author: Ming HAO ¹ ; Jiangfeng MAO ; Min NIE ; Bingqing YU ; Yinjie GAO ; Xi WANG ; Xueyan WU
Author Information

1. 中国医学科学院北京协和医学院
Keywords: Glucagon-like peptide-1; Glucagon-like peptide-1 receptor; Glucagon-like peptide-1 receptor agonists; Hypothalamus-pituitary-gonad; Gonadal diseases
From: Chinese Journal of Endocrinology and Metabolism 2019;35(6):515-518
CountryChina
Language:Chinese
Abstract: Mammalian reproduction is closely related to their metabolic status. The hypothalamus-pituitary-gonad axis ( HPG axis) is regulated by various metabolic factors. Glucagon-like peptide-1 ( GLP-1) is one of various metabolic factors that not only affect glycemic and metabolic control, but also with many other effects, including affecting HPA axis. The function of GLP-1 is related to the location of glucagon-like peptide-1 receptor ( GLP-1R) distribution. It has been confirmed that GLP-1R is widely distributed in HPG axis. The effects of GLP-1 and GLP-1R agonists on the HPG axis have also attracted much attention. The positive effects of GLP-1 and GLP-1R agonists on the HPG axis indicated it could be the new target for the new treatment for gonadal diseases. The role of GLP-1 and GLP-1R agonists in the central nervous system is reviewed.