One case of multiple system atrophy with the syndrome of Inappropriate Antidiuresis

VernacularTitle:多系统萎缩合并抗利尿激素不适当分泌综合征一例
Author: Tingting SU ¹ ; Jie LIU ; Lu GAO ; Hui GUO ; Bingyin SHE ; Wei QIANG
Author Information

1. 西安交通大学第一附属医院心血管内科 710061
Keywords: Multiple system atrophy; Syndrome of inappropriate antidiuresis; Hyponatremia; Fluid restriction
From: Chinese Journal of Endocrinology and Metabolism 2019;35(6):511-514
CountryChina
Language:Chinese
Abstract: To evaluate the diagnosis and treatment of syndrome of inappropriate antidiuresis ( SIAD ) in multiple system atrophy ( MSA ) . Clinical features and treatment of a case of MSA with SIAD was retrospectively analyzed. An MSA-cerebellar predominant ( MSA-C) type patient was admitted for being fever. Pulmonary and urinary infections were identified. The patient was characterized by euvolaemic hyponatremia with reduced plasma osmolality and increased urine sodium. Hypothyroidism and hypoadrenalism were excluded via functional tests of different hormones. The diagnosis of SIAD was made. The fever and SIAD persisted after pulmonary and urinary infections were cured. The patient was sweatless and the body temperature varied with room temperature due to dysfunction of central thermoregulation. With fluid restriction, the serum sodium return to the lower limit of normal range. Though the SIAD in MSA is rare, water and sodium balance should be carefully maintained, especially for those with pulmonary infection.