Clinical study and literature review of mifepristone in the treatment of the occult ectopic adrenocorticotropin syndrome
10.3760/cma.j.issn.1000-6699.2019.06.011
- VernacularTitle:米非司酮治疗隐匿性异位促肾上腺皮质激素综合征的临床观察及文献回顾
- Author:
Yaru LIANG
1
;
Xiaoli YAO
;
Bingyin SHI
Author Information
1. 西安交通大学医学院第一附属医院内分泌科 710061
- Keywords:
Mifepristone;
Occult;
Ectopic adrenocorticotropin syndrome;
Surgery
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(6):506-510
- CountryChina
- Language:Chinese
-
Abstract:
This is a follow-up study in two patients who were diagnosed with the occult ectopic adrenocorticotropin syndrome ( EAS) and treated with mifepristone in our hospital. The efficacy and adverse reactions of mifepristone in these two patients with EAS were investigated. The patients had significant improvement in clinical manifestations, the plasma adrenocorticotropic hormone ( ACTH) and cortisol levels decreased in patient 1, while patient 2 remained stable during the treatment. Patient 1 with diabetes mellitus stopped hypoglycemic agents, while the dose of antihypertensive drugs decreased in patient 2 with hypertension, and she was treated with surgery and suffered from transient adrenocortical insufficiency after surgical excision of the lesion. Mifepristone is effective and safe in treating EAS. Surgical treatment should be performed once the lesion is found during the follow-up.
