Relationship between genetic factors and occurrence of chronic post-thoracotomy pain syndrome:interleukin-8 and NF-kappa B1 genetic polymorphisms
10.3760∕cma.j.issn.0254-1416.2019.06.017
- VernacularTitle:遗传因素与胸科手术后慢性疼痛综合征发生的关系:IL-8和NF-κB1的基因多态性
- Author:
Fei YUAN
1
;
Jinping ZHOU
;
Aichun ZHANG
;
Lili SUN
;
Xiaohong WEN
;
Zhiying FENG
Author Information
1. 浙江大学医学院附属第一医院麻醉疼痛科
- Keywords:
Pain;
postoperative;
Polymorphism;
genetic;
Interleukin-8;
NF-kappa B1
- From:
Chinese Journal of Anesthesiology
2019;39(6):703-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of genetic factors on the occurrence of chronic post-thoracotomy pain syndrome ( PTPS) from the perspective of genetic polymorphisms. Methods Two hun-dred patients of both sexes, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, aged 18-80 yr, scheduled for elective video-assisted thoracoscopic radical lung cancer surgery, were enrolled in this study. Blood samples were taken before operation for genotype analysis of 20 SNP loci, such as rs4073 and rs3774932, after DNA extraction. Postoperative multimodal analgesia was applied to maintain the visual an-alogue scale score ＜3. All the patients were followed up for 2-4 months after operation to record the occur-rence of PTPS. The patients were divided into 2 groups according to whether PTPS occurred: non-PTPS group (group N) and PTPS group (group P). Results The incidence of PTPS was 38. 7％ after surgery, and there were 114 patients in group N and 72 cases in group P . There was significant difference in A/T al-lele and genotype frequency at interleukin-8 rs4073 site and NF-κB1 rs3774932 site between the two groups (P＜0. 05). Conclusion Interleukin-8 and NF-kappa B1 genetic polymorphisms are associated with the occurrence of PTPS.
