Relationship between prefrontal cortex and propofol-induced cognitive dysfunction in rats
10.3760∕cma.j.issn.0254-1416.2019.06.013
- VernacularTitle:前额叶皮层与丙泊酚诱发大鼠认知功能障碍的关系
- Author:
Bo CAO
1
;
Pan WANG
;
Chao ZHANG
;
Yang CHEN
;
Jianteng GU
;
Bin YI
;
Kaizhi LU
;
Jinquan WANG
Author Information
1. 重庆市南川区中医院手术麻醉科 408400
- Keywords:
Propofol;
Prefrontal cortex;
Cognition disorders
- From:
Chinese Journal of Anesthesiology
2019;39(6):688-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between prefrontal cortex and propofol-induced cognitive dysfunction in rats. Methods SPF healthy male Sprague-Dawley rats, weighing 300-350 g, aged 16 weeks, were used in this study. Thirty rats in which catheters were successfully implanted into the prefrontal lobe were divided into 2 groups ( n=15 each ) using a random number table method: control group (group C) and propofol group (group P). In group P, 50μmol/L propofol 0. 5μl was microinjected into the prefrontal cortex at day 7 after operation, and the equal volume of normal saline was given instead in group C. T-maze test and open field test were performed at 15 min after administration. Results Com-pared with group C, the correct rate of selection in T-maze was significantly decreased ( P＜0. 05) , and no significant change was found in the total locomotor or number of rearing in open field test in group P ( P＞0. 05) . Conclusion Prefrontal cortex may be involved in propofol-induced cognitive dysfunction in rats.
