Effects of different concentrations of desflurane on electrophysiological stability of hearts in female patients
10.3760/cma.j.issn.0254-1416.2019.05.006
- VernacularTitle:不同浓度地氟醚对女性患者心脏电生理稳定性的影响
- Author:
Yanqiu LIU
1
;
Hong GAO
;
Li AN
;
Yimin REN
;
Xiaokui FU
;
Suisui HUANG
Author Information
1. 贵州医科大学附属医院麻醉科
- Keywords:
Anesthetics,inhalation;
Femininity;
Cardiac electrophysiology
- From:
Chinese Journal of Anesthesiology
2019;39(5):534-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different concentrations of desflurane on the electrophysiological stability of hearts in female patients.Methods Forty female patients,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,aged 20-50 yr,weighing 45-77 kg,scheduled for elective surgery with general anesthesia,were divided into 2 groups (n =20 each) using a random number table method:0.6 MAC group (group D1) and 1.3 MAC group (group D2).The intravenous access was opened after admission to the operating room,midazolam 0.1 mg/kg,vecuronium 0.1 mg/kg,fentanyl 3 μg/kg and etomidate 0.3 mg/kg were injected intravenously,and mechanical ventilation was performed after tracheal intubation.The concentrations of desflurane reached 0.6 and 1.3 MAC in D1 and D2 groups,respectively.Twelve-lead electrocardiograms were collected before anesthesia induction (T1),at 5 min after intubation (T2) and at 20 min after reaching the set concentration of desflurane (T3).The QT interval and Tpe interval were measured,the QTc interval,Tp-e/QT ratio and index of cardiac electrophysiological balance were calculated,and the development of arrhythmia was also observed.Results The QT interval and QTc interval were significantly longer,and the Tp-e/QT ratio was lower at T3 than at T1,2 in two groups (P＜ 0.05).There was no significant difference in QT interval,Tp-e/QT ratio or index of cardiac electrophysiological balance at each time point between two groups (P＞0.05).No arrhythmia was found in neither group.Conclusion The clinical concentration of desflurane affects the electrophysiological stability of hearts to some extent in female patients without causing arrhythmia.
