Median effective dose of etomidate inducing electroencephalogram burst suppression in patients with non-intracranial diseases
10.3760/cma.j.issn.0254-1416.2019.02.024
- VernacularTitle:依托咪酯诱发非颅内疾病患者脑电爆发抑制的半数有效剂量
- Author:
Huimin CHEN
1
;
Yuechun LU
;
Jian SUN
;
Huanhuan LYU
;
Haiqian QIN
Author Information
1. 天津医科大学第二医院麻醉科 300211
- Keywords:
Etomidate;
Brain waves;
Dose-response relationship,drug
- From:
Chinese Journal of Anesthesiology
2019;39(2):218-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the median effective dose (EDs0) of etomidate inducing electroencephalogram (EEG) burst suppression (BS) in the patients with non-intracranial diseases.Methods American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients of both sexes,aged 18-64 yr,with body mass index of 19-27 kg/m2,scheduled for elective non-intracranial surgery,were enrolled in this study.ED50 of etomidate was determined by Dixon's up-and-down sequential method.Etomidate was intravenously injected for 30 s at an initial dose of 0.30 mg/kg.The BS ratio was recorded within 6 min following the end of injection.Each time ED50 increased/decreased in the next patient depending on whether or not BS occurred.The difference between the two successive doses was 0.05 mg/kg.Successful induction of BS was defined as BS ratio＞ 10％,lasting more than 1 min.Probit analysis was used to calculate the ED50 and 95％ confidence interval of etomidate inducing EEG BS in the patients with non-intracranial diseases.Results The ED50 of etomidate inducing EEG BS was 0.70 mg/kg,and the 95％ confidence interval was 0.65-0.81 mg/kg in the patients with non-intracranial diseases.Conclusion The ED50 of etomidate inducing EEG BS is 0.70 mg/kg in the patients with non-intracranial diseases.
