Protective effects of stilbene glycoside on 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine induced mice model of Parkinson's disease
10.3760/cma.j.issn.0254-9026.2019.08.025
- VernacularTitle:二苯乙烯苷对帕金森病模型小鼠的保护作用
- Author:
Jianying HE
1
;
Haofei YU
;
Ju LI
;
Shuda YANG
;
Yuan LI
;
Rongping ZHANG
;
Weiyan HU
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室
- Keywords:
Parkinson disease;
Stilbenes;
1-methy-4-phenyl-1,2,3,6-tetrahydropyridine
- From:
Chinese Journal of Geriatrics
2019;38(8):929-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of stilbene glycoside(2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside,TSG) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease(PD).Methods Mice were randomly divided into the blank control group,the negative control group,the TSG high-dose group,the TSG low-dose group and the positive drug group(n=20 each).Mice were weighted daily to observe the changes of body weight,and mice motor and behavior function were tested by open field test.Level changes of α/β synuclein in brain cortex,cerebellum,midbrain,and hippocampal were detected by Western blot.Results Compared with the blank control group,the negative control group showed that the body weight was decreased (P ＜ 0.05).Compared with the negative control group,the body weight was increased in the TSG high-and low-dose groups and the positive drug group (P ＜ 0.05).The spontaneous behavior was impaired in the negative control group.Compared with the blank control group,the negative control group showed that the open field test showed traveled distance over a 10-min period was significantly shortened at 1 st,7th,28th days after testing(all P＜0.05).The trajectory of motor axons indicated that mice in the negative control group showed dyskinesia,but the groups of positive drug and high-and low-dose of TSG could reverse this dyskinesia.Compared with the blank control group,brain α/β synuclein protein levels were increased in the negative control group,and decreased in positive drug and TSG high-and low-dose groups (P ＜0.05).Conclusions Stilbene glycosides exert neuroprotective effects in MPTP-induced mice model of PD.
