Macrophages, myofibroblasts and mast cells in a rat liver infected with Capillaria hepatica.
- Author:
Won Il JEONG
1
;
Sun Hee DO
;
Il Hwa HONG
;
Ae Ri JI
;
Jin Kyu PARK
;
Mi Ran KI
;
Seung Chun PARK
;
Kyu Shik JEONG
Author Information
- Publication Type:Case Report ; Case Reports ; Research Support, Non-U.S. Gov't
- Keywords: Capillaria hepatica; fibrosis; liver; rat
- MeSH: Animals; *Capillaria; Enoplida Infections/immunology/parasitology/*veterinary; Fibroblasts/immunology; Liver/parasitology/pathology; Macrophages/immunology; Mast Cells/immunology; Rats; Rodent Diseases/*immunology/*parasitology/pathology
- From:Journal of Veterinary Science 2008;9(2):211-213
- CountryRepublic of Korea
- Language:English
- Abstract: We trapped a rat (Rattus norvegicus) infected with Capillaria hepatica. At necropsy, grossly yellowish-white nodules (2-3 mm in diameter) were noted to be scattered on the liver's surface. Microscopically, granulomatous and fibrotic nodules that contained the eggs and/or adult worms of Capillaria hepatica were detected in the liver. Septal fibrosis was diffusely formed throughout the liver. There were a number of ED1-positive macrophages located in the sinusoids of the pseudolobules. On the double staining, myofibroblasts and mast cells were generally observed within the fibrous septa with the mast cells in close proximity to the myofibroblasts. We suggest that the interactions between macrophages, myofibroblasts and mast cells play a role in the septal fibrosis observed in rats infected by Capillaria hepatica.
