Comparison between superb microvascular imaging and histopathology for the evaluation of carotid artery atherosclerotic plaque neovascularization
10.3760/cma.j.issn.1674-0815.2019.02.003
- VernacularTitle:超微血管显像技术评价颈动脉粥样硬化斑块新生血管及病理对照分析
- Author:
Xuanjia CHEN
1
,
2
;
Hongyan WANG
;
Yuxin JIANG
;
Jianchu LI
;
Na LI
;
Jing KONG
;
Xiaoyan ZHANG
;
Wei YE
;
Dachun ZHAO
Author Information
1. 中国医学科学院北京协和医院超声诊断科 100730
2. 北京市通州区妇幼保健院超声科 101121
- Keywords:
Ultrasonography;
Carotid arteries;
Atherosclerosis;
Neovascularization;
Histopathology
- From:
Chinese Journal of Health Management
2019;13(2):108-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of superb microvascular imaging (SMI) for the detection of neovascularization in carotid atherosclerotic plaques.Methods SMI detected 28 carotid atherosclerotic plaques in 28 patients who underwent carotid endarterectomy.The SMI grade of carotid plaque neovascularization was assigned based on the following grading system:Grade 0,no neovascularization;grade 1,some neovascularization;grade 2,neovascularization observed in the shoulder of the plaque;and grade 3,widely distributed new blood vessels.SMI was used to evaluate the degree of blood flow,maximum flow velocity,and resistance index of the new vessels in the plaque.Microvascular density was measured with CD31 staining.Results Clear correlations were observed between neovascularization density on histopathological staining of the plaque and the degree of blood flow detected with SMI (rs=0.788,P ＜ 0.001).The classification of neovascular blood flow in the plaque was positively correlated with plaque thickness (rs=0.686,P=0.002).Of the 28 cases,neovascularization was detected in 23;of these 23 cases,the direction of blood flow was from the adventitia to the intima in 17 (75％) cases,while 6 (25％) cases showed an irregular direction of blood flow.The mean neovascular flow velocity was (5.620±0.131) cm/s,and the mean neovascular resistance index was 0.660 ± 0.090.Conclusion SMI is useful for the evaluation of carotid atherosclerotic plaque neovascularization.
