Methodological progress of 18 F-labeled aromatic PET radiotracers
10.3760/cma.j.issn.2095-2848.2019.08.012
- VernacularTitle:18F标记芳环类PET显像剂方法的研究进展
- Author:
Wangjun GU
1
;
Mingqiao ZHU
;
Zheng LI
;
Rong REN
;
Qinggang HE
;
Hong ZHANG
Author Information
1. 浙江大学化学工程与生物工程学院
- Keywords:
Hydrocarbons;
aromatic;
Isotope labeling;
Fluorine radioisotopes;
Positron-emission;
tomography;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(8):499-503
- CountryChina
- Language:Chinese
-
Abstract:
PET serves as one of the most advanced imaging modalities,and its development depends on the improvement of radiotracers.Among numerous positron isotopes,18 F appears to be the best radionuclide candidate for PET radiotracers by virtue of its favorable physical characteristics.18 F-labeled aromatic radiotracers have been widely investigated by researchers due to its special metabolic stability.However, the development and application of 18 F-labeled aromatic radiotracers have been limited due to lacking of radiochemical methods to obtain products with high selectivity,high radioactivity and high purity.This review focuses on the new labeling methods of 18 F-labeled aromatic radiotracers from the aspects of electrophilic and nucleophilic substitution reactions.
