Clinical application of 18 F-FDOPA PET/CT imaging in the diagnosis of pheochromocytoma/para-ganglioma
10.3760/cma.j.issn.2095-2848.2019.08.005
- VernacularTitle:18F-FDOPA PET/CT显像在嗜铬细胞瘤/副神经节瘤诊断中的临床应用
- Author:
Zhiwei GUAN
1
;
Guangyu MA
;
Xiaojun ZHANG
;
Huaping FU
;
Li ZANG
;
Jinming ZHANG
;
Baixuan XU
Author Information
1. 解放军总医院核医学科
- Keywords:
Pheochromocytoma;
Paraganglioma;
Levodopa;
Fluorine radioisotopes;
Positron-emission tomography;
Tomography;
X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(8):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficiency of 6-18 F-fluoro-L-3,4-dihydroxyphenylalanine (18 F-FDOPA) PET/CT imaging in the diagnosis of pheochromocytoma/paraganglioma (PPGLs). Methods Twenty-six patients (15 males, 11 females;age:13-76 years) who were suspected of PPGLs with adrenal or retro-peritoneal mass were enrolled into this prospective study. All patients underwent 18 F-FDOPA PET/CT ima-ging. The clinical data, laboratory data and imaging results were collected. Region of interest ( ROI) was drawn on the liver and lesions, and the mean standardized uptake value ( SUVmean ) of the liver and the max-imum standardized uptake value ( SUVmax ) of lesions were calculated, as well as the ratio of tumor/lesion ratio ( T/L) . Based on the pathological results considered as the gold standard, the diagnostic efficiency of 18 F-FDOPA PET/CT imaging in PPGLs was calculated and compared with that of CT/MR. Besides, receiv-er operating characteristic ( ROC) curve analysis of T/L was used. Results Twenty-five patients were path-ologically confirmed, including 12 patients with PPGLs and 13 patients with non-PPGLs. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 18 F-FDOPA PET/CT ima-ging was 11/12, 12/13, 92.00％(23/25), 11/12 and 12/13, respectively. The area under the ROC curve of T/L was 0.978, with the cut-off value of 1.55. 18 F-FDOPA PET/CT imaging totally detected 29 positive foci, including 12 of pheochromocytoma (PCC) and 17 of paraganglioma (PGL). Among those 18F-FDOPA positive PGL foci, 11 were detected by CT/MR, while 6 with diameter less than 1 cm were missed. Conclu-sion 18 F-FDOPA PET/CT imaging can detect more small PGL lesions than CT/MR, suggesting that it may be a proper imaging modality of PPGLs.
