Value of 123 I-MIBG SPECT/CT imaging in the diagnosis and treatment of pediatric neuroblastoma
10.3760/cma.j.issn.2095-2848.2019.08.004
- VernacularTitle:123I-MIBG SPECT/CT显像在儿童神经母细胞瘤诊治中的价值
- Author:
Wei WANG
1
;
Jun LIU
;
Leilei YUAN
;
Ying KAN
;
Jie LIU
;
Jigang YANG
Author Information
1. 首都医科大学附属北京友谊医院核医学科 100050
- Keywords:
Neuroblastoma;
Child;
3-iodobenzylguanidine;
Iodine radioisotopes;
Tomography;
emission-computed;
single-photon;
Tomography;
X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(8):464-467
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of 123I-metaiodobenzylguanidine (MIBG) SPECT/CT imaging in the diagnosis and treatment of pediatric patients with neuroblastoma ( NB) . Methods A total of 196 NB patients (103 males, 93 females;age 1-14 years) who underwent 123I-MIBG SPECT/CT imaging in Beijing Friendship Hospital between February 2018 and December 2018 were reviewed retrospec-tively. All patients underwent whole-body planar imaging and local SPECT/CT imaging. According to the clinical data and 123 I-MIBG imaging results, patients were divided into 3 groups ( group 1: patients under-went preoperative planar imaging; group 2: patients with positive results in postoperative planar imaging;group 3:patients with negative results in postoperative planar imaging). The final diagnosis was made ac-cording to pathological results, other related imaging results and clinical follow-up results. The diagnostic consistency between planar imaging or SPECT/CT imaging and final diagnosis in each group was calculated and compared using χ2 test. Results For group 1 ( n=34) , the diagnostic consistencies of planar imaging and SPECT/CT imaging with the final diagnosis were 38.2％(13/34) and 82.4％(28/34) respectively (χ2=13.82, P<0.01), while those were 13.3％(12/90) and 74.4％(67/90) for group 2 (n=90;χ2=68.24, P<0. 01). In these two groups, SPECT/CT imaging improved the planar imaging results by 44.12％(15/34) and 61.11％(55/90) respectively. For group 3 (n=72), the diagnostic consistencies of planar imaging and SPECT/CT imaging with the final diagnosis were 88.9％(64/72) and 94.4％(68/72;χ2=1.45, P>0.05), and planar imaging results in only 5.56％(4/72) patients were improved by SPECT/CT imaging. Conclu-sions For patients undergoing preoperative imaging and those with positive results in postoperative planar imaging, SPECT/CT imaging should be added. For patients with negative results in postoperative planar im-aging, unnecessary SPECT/CT imaging should be limited.
