Preliminary exploration of 18 F-FMISO PET/CT SUVmax with relevant factors for nasopharyngeal carcinoma
10.3760/cma.j.issn.2095-2848.2019.07.002
- VernacularTitle:影响鼻咽癌18F-FMISO乏氧显像SUVmax的相关因素初探
- Author:
Najing WU
1
;
Qiaoling XU
;
Xuyang YOU
;
Bo YANG
;
Wei CAI
;
Liping CHEN
;
Yu ZHANG
;
Leyuan ZHOU
Author Information
1. 江南大学附属医院、无锡市第四人民医院核医学科 214062
- Keywords:
Nasopharyngeal neoplasms;
Cell hypoxia;
Nitroimidazoles;
Fluorine radioisotopes;
Positron-emission tomography;
Tomography;
X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(7):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the maximum standardized uptake value ( SUVmax ) of 18 F-fluoromisonidazole ( FMISO) PET/CT and the pathological classification, differentiation, T stage and primary tumor volume of nasopharyngeal carcinoma ( NPC) . Methods A retrospective analysis was performed on 41 patients with NPC (31 males, age 18-74 years;10 females, age 35-67 years) who underwent head and neck 18 F-FMISO PET/CT from 2012 to 2015. The relationship between the clinicopath-ological parameters (pathological classification, differentiation, T stage, tumor volume) of primary lesion and SUVmax were analyzed. Mann-Whitney u test, approximate t test and Spearman correlation were used for data analysis. Results There was no significant difference in SUVmax between non-keratinizing carcinoma and squamous cell carcinoma ( u=183.5, P>0.05) , nor between the differentiated carcinoma and undiffer-entiated carcinoma( t'=-1.23, P>0.05) . SUVmax of T1-T2 primary tumor was significantly lower than that of T3-T4 tumor (1.52±0.43 vs 2.05±0.85; t'=-2.60, P<0.05), and SUVmax was correlated with primary tumor volume ( rs=0.488, P<0.05) . Conclusions The hypoxic degree is related with T stage and primary tumor volume in NPC. The combination analysis of T stage and tumor size will contribute to the assessment of oxygen level and prognosis of primary NPC.
