Changes of dopamine D2 receptor in patients with insomnia and its clinical significance
10.3760/cma.j.issn.2095-2848.2019.07.001
- VernacularTitle:失眠障碍患者脑多巴胺D2受体改变及其意义初探
- Author:
Yang YOU
1
;
Hongju ZHANG
;
Ang XUAN
;
Jie ZHANG
;
Chang FU
;
Mengmeng SUN
;
Yongju GAO
;
Dapeng SHI
;
Junling XU
Author Information
1. 河南省人民医院、郑州大学人民医院核医学科PET/CT中心 450003
- Keywords:
Sleep initiation and maintenance disorders;
Receptors;
dopamine;
Raclopride;
Carbon radioisotopes;
Positron-emission tomography;
Tomography;
X-ray computed;
Magnetic resonance imaging
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(7):385-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of dopamine D2 receptor in dopamine pathway in in-somnia patients and discuss its clinical significance. Methods From January 2016 to December 2016, 15 patients with insomnia (1 male, 14 females, age:(44.3±8.6) years) and 15 gender-/age-matched-healthy volunteers (control group;3 males, 12 females, age:(40.5±9.0) years) were included to undergo resting brain 11C-Raclopride PET/CT imaging. The D2 receptor binding potential (BPND) of the dopamine pathway was calculated by molecular imaging and kinetic analysis toolbox ( MIAKAT) software. The BP ND , Hamilton depression scale ( HAMD) , transient and graphics memory scale results were compared with two-sample t test and Mann-Whitney u test between the two groups. Pearson correlation analysis was used to evaluate the correlation between BPND(nucleus accumbens, caudate nucleus, putamen) and Pittsburgh sleep quality in-dex ( PSQI) , HAMD, course of disease, transient memory and graphical memory scale scores in the patient group. Results The BP ND in bilateral putamen, nucleus accumbens and left caudate nucleus of patients was lower than that of controls( left putamen:z=-2.717, right putamen:z=-2.883, both P<0.01;left nu-cleus accumbens:t=-2.269, right nucleus accumbens:t=-2.410, both P<0.05;left caudate nucleus:t=-2.632,P<0. 05), but the BPND level of right caudate nucleus was not significantly different(z=-0.850, P>0.05) . The scores of HAMD in the patient group were higher than those in control group ( t=10. 273, P<0. 01), while the scores of instantaneous memory (t=-4.888, P<0.01) and graphical memory scale (t=-2.624, P<0.05) were lower. There were significant negative correlations between the BP ND of bilateral nucleus ac-cumbens, caudate nucleus and putamen and the course of insomnia in the patient group ( r range:-0.761 to-0.682, all P<0.01) . Conclusion Patients with insomnia have abnormal neurotransmitter system of dopa-mine D2 and it may play a role in the pathogenesis of insomnia.
