Research progress of the relationship between chronic inflammation and pancreatic ductal adenocarcinoma
10.3760/cma.j.issn.1007-8118.2019.08.020
- VernacularTitle:慢性炎症与胰腺导管腺癌关系的研究进展
- Author:
Chunyan LI
1
;
Yong HU
;
Yunfeng CUI
Author Information
1. 天津医科大学研究生院
- Keywords:
Pancreatitis,chronic;
Pancreatic intraductal neoplasms;
NF-kappa B;
STAT3 transcription factor;
Pancreatic neoplasms
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(8):636-640
- CountryChina
- Language:Chinese
-
Abstract:
Studies have demonstrated a strong correlation between chronic inflammation and tumor initiation and progression.Chronic intlammation is mainly involved in tumor progression through intrinsic and extrinsic pathways,and transcription factors such as NF-κB and STAT3 play important roles.Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies.Chronic inflammation can promote the development of PDAC in cooperation with mutation of protooncogene.Inflammation signaling pathway plays an important role in malignant transformation in the PDAC,in which NF-κB and STAT3 are two major transcription factors.Targeting the key regulator points based on the crosstalk between inflammation signaling and PDAC may potentially represent a novel for PDAC prevention and treatment.This article briefly reviews the role of chronic inflammation in the development of PDAC,the PDAC-related inflammatory signal network caused by chronic inflammation,and crosstalk between NF-κB and JAK/STAT3 signaling pathways.
