Clinical characteristics of 27 patients with type 1 autoimmune pancreatitis
10.3760/cma.j.issn.1007-8118.2019.08.008
- VernacularTitle:1型自身免疫性胰腺炎27例临床特征
- Author:
Mengshi CHEN
1
;
Xiaoyu LIANG
;
Zhihui LIN
;
Longhao SUN
Author Information
1. 福建省立医院消化内科
- Keywords:
Pancreatitis;
Immunoglobulin G;
Cholangiopancreatography,magnetic resonance;
Autoimmune pancreatitis;
Treatment outcome
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(8):592-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of type 1 autoimmune pancreatitis (AIP) in patients.Methods The clinical data of 27 patients with type 1 AIP treated at Fujian Provincial Hospital from January 2012 to October 2018 were retrospectively analyzed.Results There are 25 males (92.6%) and 2 females (7.4%) (ratio 12.5∶1).The age of disease onset was (59.5 ± 14.3) years.The most common presenting symptoms were jaundice and abdominal pain (both 59.3%).The most common complication was IgG4-related sclerosing cholangitis (63.0%).Magnetic Resonance Cholangiopancreatograhpy (MRCP) conducted on 26 patients showed the diffuse type 1 AIP was most common (53.8%),only 2 patients (7.7%) presented with a main pancreatic duct stricture.The pancreatic segment of bile duct narrowing was very common (84.6%),and most patients presented as tapered narrowings (65.4%).Standard glucocorticoid therapy was given to these 27 patients who responded well with clinical and laboratory remissions.Two patients were given maintenance glucocorticoid therapy for a high level of serum IgG4.Conclusions Type 1 AIP can present as a local manifestation of IgG4-related disease.The most common complication is IgG4-related sclerosing cholangitis.Glucocorticoid therapy was effective but some patients required maintenance therapy.