Expression of cancer susceptibility candidate 2 in hepatocellular carcinoma and its influence on the prognosis of the patients
10.3760/cma.j.issn.1007-8118.2019.08.001
- VernacularTitle:癌易感性候选基因2在肝细胞癌中的表达及其对患者预后的影响
- Author:
Yuxian ZHANG
1
;
Haijun DU
;
Diangang LIU
;
Xiang GAO
;
Yuehua WANG
;
Cong LI
;
Jushan WU
Author Information
1. 北京市回民医院消化科 100054
- Keywords:
Carcinoma,hepatocellular;
Prognosis;
RNA,long non-coding;
Cancer susceptibility candidate 2
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(8):561-564
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations between expression of CASC2 and hepatocellular carcinoma(HCC) prognosis.Methods A total of 129 patients including 80 males and 49 females with HCC were includedin this study,ranging from 21 to 73 years in Xuanwu Hospital of Capital Medical University and Beijing You'an Hospital were retrospectively analyzed from September 2007 to January 2014.Expression of CASC2 was assessed using reverse transcription quantitative-polymerase chain reaction in HCC tissue and the adjacent normal tissue.The correlations between CASC2 mRNA level and clinicopathological parameters was investigated.The relationship between the expression of CASC2 and the prognosis of patients with HCC was analyzed by Kaplan-Meier method.A log-rank analysis was performed to identify group differences.Univariate and multivariate Cox analysis were used to analyze the variables affecting the patient's prognosis.Results In 129 HCC samples,the level of CASC2 expression (0.84 ± 0.05) was lower than (3.35 ± 0.11) adjacent normal tissue (P ＜ 0.05).There were significant differences between CASC2 expression and tumor size,histological differentiation,and tumor stage in 129 HCC speciments.The median expression level of CACS2 in HCC tissues,0.84-fold,was used as the cut-off value to divide the 129 patients into two groups:low-expression group (n =72) and high-expression group (n =57).Overall survival rate of HCC patients with high CACS2 expression was significantly higher than those of patients with low CACS2 expression(P ＜0.05).Multivariate analysis indicated that histological differentiation (HR =0.20,95％ CI:0.05 ～ 0.59),tumor stage (HR =1.71,95％ CI:1.02 ～ 2.99) and CACS2 expression (HR =O.51,95％ CI:O.08 ～0.92) were an independent predictor of overall survival.Conclusion Low expression of CACS2 might be associated with the occurrence and development of HCC.
