Meta-analysis of treatment strategies for post-hepatectomy recurrent hepatocellular carcinoma:salvage liver transplantation or repeat hepatectomy
10.3760/cma.j.issn.1007-8118.2019.07.008
- VernacularTitle:补救性肝移植和再次肝切除治疗复发肝癌疗效对比的荟萃分析
- Author:
Hongliang WANG
1
;
Xuyong SUN
;
Jianhui DONG
;
Liugen LAN
;
Jihua WU
;
Haibin LI
;
Zhuangjiang LI
Author Information
1. 中国人民解放军联勤保障部队第九二三医院移植医学研究院 广西移植医学重点实验室 广西移植医学工程技术研究中心
- Keywords:
Recurrence;
Carcinoma,hepatocellular;
Liver transplantation;
Reoperation;
Meta-analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(7):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness of salvage liver transplantation ( SLT) versus repeat hepatectomy (RH) in post-hepatectomy recurrent hepatocellular carcinoma. Methods Data from 1 January 1990 to 31 July 2018 were retrieved from the Cochrane library, PubMed, EMbase, Wan Fang Data, CBM, CNKI, VIP and other databases. The collected publications were all on case-control studies comparing SLT with RH for post-hepatectomy recurrent hepatocellular carcinoma. The literatures’ quality and the data of each study were evaluated and analyzed using RevMan. Relative risk (RR) and 95% confidence interval (CI) were used. Results Five articles which included 525 patients were enrolled. There were no signifi-cant differences between SLT and RH on the 1-, 3-and 5-year overall survival (P＞0. 05 for all). Howev-er, for the 1-year (RR=2. 86, 95% CI: 1. 37～5. 97, P＜0. 05), 3-year (RR=2. 57, 95% CI: 0. 99～6. 70, P=0. 05), and 5-year disease-free survivals (RR=4. 79, 95% CI: 1. 88～12. 25, P＜0. 05), PLT was significantly better than RH. Conclusion The effectiveness of SLT was superior to RH in the treatment of post-heptectomy recurrent hepatocellular carcinoma. However, considering the similar overall survival rates, RH is still an important treatment option for post-hepatectomy recurrent hepatocellular carcinoma because of liver donor shortage.
