Advances in Research on anoikis resistance of hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2019.05.020
- VernacularTitle:肝细胞癌的失巢凋亡抵抗作用研究进展
- Author:
Xuemei LI
1
;
Jike HU
;
Baohong GU
;
Fan ZHANG
;
Dengfeng WANG
;
Pengxian TAO
;
Yajing CHEN
;
Hao CHEN
Author Information
1. 兰州大学第二临床医学院
- Keywords:
Anoikis;
Signal transduction;
Carcinoma,hepatocellular;
Neoplasm metastasis
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(5):390-393
- CountryChina
- Language:Chinese
-
Abstract:
The anoikis resistance confers the ability of cancer cells to survive and metastasize in the blood circulation without adhesion,but its effect and mechanism in intrahepatic and distant metastasis of hepatocellular carcinoma has not been fully elucidated.Recent studies have shown that certain factors or drugs may inhibit anoikis of hepatoma cells through some signaling pathways.These signaling pathways are not completely separated,they are interconnected to promote metastasis of hepatocellular carcinoma.Liver is the metabolic center of many substances,and many related factors can promote metastasis of hepatocellular carcinoma through inhibiting anoikis.In this review,we summarized the signaling pathways of anoikis resistance of hepatocellular carcinoma.
