Progresses in research of hypoxia inducible factor-1α in radiosensitivity of cervical cancer
10.3760/cma.j.issn.1004-4221.2019.08.017
- VernacularTitle:缺氧诱导因子-1α与宫颈癌放射敏感性的研究进展
- Author:
Quhui HU
1
;
Li HAN
;
Xiao HE
;
Shikun YANG
Author Information
1. 三峡大学医学院生物病原与免疫学系
- Keywords:
Cervical cancer;
Hypoxia-inducible factor;
Radiosensitivity
- From:
Chinese Journal of Radiation Oncology
2019;28(8):630-633
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-α ( HIF-1α) is a regulatory protein in human body, which is closely related to the occurrence and development of cervical cancer. HIF-1α is an important factor affecting the radiosensitivity of cervical cancer. Many genes and proteins are involved in the regulation of radiosensitivity by HIF-1α. These genes and proteins are directly or indirectly affecting the efficacy of radiotherapy for cervical cancer. A lot of research is under way. This review summarizes the recent advances in genes and proteins associated with HIF-1α affecting radiosensitivity in cervical cancer.
