Relationship between Vimentin Expression and Progression of Uterine Cervix Epithelial Neoplasms.
- Author:
Sung Chul LIM
;
Keun Hong KEE
;
Hyun Jong PARK
- Publication Type:In Vitro ; Original Article
- Keywords:
Uterine cervix;
Squamous cell carcinoma;
Vimentin;
Tumor progression;
Metastasis
- MeSH:
Carcinogenesis;
Carcinoma, Squamous Cell;
Cervical Intraepithelial Neoplasia;
Cervix Uteri*;
Female;
Humans;
Intermediate Filaments;
Lymph Nodes;
Neoplasm Metastasis;
Neoplasms, Glandular and Epithelial*;
Vimentin*
- From:Korean Journal of Pathology
1998;32(9):663-669
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vimentin is an intermediate filament protein normally expressed in mesenchymal cells, but the evidence of the aberrant expression of vimentin in epithelial cancer cells suggests that the vimentin expression might be related to local invasiveness and metastatic potential. There have been a few previous studies on the vimentin expression in human cervical carcinogenesis using in vivo and in vitro models. We examined the immunohistochemical vimentin expression in various squamous epithelial neoplasms of the uterine cervix, including the cervical intraepithelial neoplasia group (n=25), the microinvasive squamous cell carcinoma group (n=15), the invasive squamous cell carcinoma group (n=15) and the metastatic squamous cell carcinoma group (n=8). Vimentin positivity was significantly higher in the invasive than in the intraepithelial group, and in the cases with lymph node metastasis than in those without metastasis, suggesting a relationship between the vimentin expression and progression of the uterine cervical epithelial tumors.
