Research progress of S1PR1 in tumor metastasis-promoting and radiotherapy resistance

VernacularTitle:鞘氨醇-1-磷酸受体-1促进肿瘤转移与放疗抵抗的研究进展
Author: Mengdan GAO ¹ ; Xuxue YE ; Lihuai LU ; Qiongqiong WANG ; Qingyu ZHOU ; Ya GAO ; Yifei LI ; Congying XIE
Author Information

1. 温州医科大学附属第一医院放化疗科 325000
Keywords: S1PR1; Metastasis; Radiotherapy resistance
From: Chinese Journal of Radiological Medicine and Protection 2019;39(8):599-602
CountryChina
Language:Chinese
Abstract: Distant metastasis is one of the main obstacles to cancer treatment.Overexpression of S1PR1 in malignant tumors enhances cell invasion and migration activity,mediates EMT and induces lymphangiogenesis and angiogenesis via activation of its downstream signaling pathways,eventually results in the occurrence of tumor metastasis.S1PR1 is also closely related to generation of acquired radiotherapy resistance.This article discusses the roles of S1PR1 in tumor metastasis and radiotherapy resistance.