OAR predicted dose distribution and gEUD based treatment planning optimization for IMRT
10.3760/cma.j.issn.0254-5098.2019.06.004
- VernacularTitle:基于危及器官预测剂量分布与gEUD混合目标的调强放疗计划优化
- Author:
Qiyuan JIA
1
;
Futong GUO
;
Aiqian WU
;
Mengke QI
;
Yanhua MAI
;
Fantu KONG
;
Linghong ZHOU
;
Ting SONG
Author Information
1. 南方医科大学生物医学工程学院
- Keywords:
3D dose distribution prediction;
Prediction guided treatment planning optimization;
Equivalent uniform dose;
Intensity modulated radiation therapy
- From:
Chinese Journal of Radiological Medicine and Protection
2019;39(6):422-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To propose a treatment planning optimization algorithm which can make full use of OAR dose distribution prediction meanwhile improving the output planning quality as much as possible.Methods We had reformulated an FMO function under the guidance of dose distribution prediction and also integrated equivalent uniform dose (gEUD) based on the consideration of prediction uncertainty,for providing optimal solution.Performance of the method was evaluated by comparing the optimized IMRT plan quality of 8 cervical cancers in the term of DVH curves,dose distribution and dosimetric endpoints with the original ones.Results The proposed method had a feasible,fast solution.Compared with original plan,its output plan had better plan quality in better dose homogeneity,less hot spot and further dose sparing for OARs.V30,V45 of rectum was decreased by (6.60±3.53)％ and (17.03±7.44)％,respectively,with the statistically significant difference (t=-4.954,-6.055,P＜0.05).V30,V45 of bladder was decreased by (14.74 ± 5.61) ％ and (14.99 ± 4.53) ％,respectively,with the statistically significant difference (t=-6.945,-8.759,P＜0.05).Conclusions We have successfully developed a predicted dose distribution and equivalent uniform dose-based planning optimization method,which is able to make good use of 3D dose prediction and ensure the output plan quality for intensity modulated radiation therapy.
