The feasibility of chemical exchange saturation transfer imaging of myocardial creatine metabolites:a 3.0 T MR study in phantom model
10.3760/cma.j.issn.1005?1201.2019.06.004
- VernacularTitle:3.0 T MRI化学交换饱和位移成像对心肌肌酸代谢可行性的实验研究
- Author:
Chunchao XIA
1
;
Junru LI
;
Kun ZHANG
;
Lihong ZHAO
;
Fei ZHAO
;
Kai ZHANG
;
Jin PU
;
Yingkun GUO
;
Li Zhenlin
Author Information
1. 四川大学华西医院放射科
- Keywords:
Magnetic resonance imaging;
Creatine;
Chemical exchange saturation transfer;
Electrocardiogram
- From:
Chinese Journal of Radiology
2019;53(6):459-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of chemical exchange saturation transfer (CEST) imaging in the measurement of myocardial creatine (Cr) metabolites in phantom model using 3.0 T MR. Methods Five phantoms were made according to the volume percentage of Cr ranging from 10 to 50 mmol/L with an interval of 10 mmol/L. 3.0 T MR examinations with base protocol sequence,sequence with and without ECG were performed. Signal to noise,CrEST effect and Z spectra were analyzed. Comparison of signal noise ratio (SNR) among the three methods was performed using an analysis of variance. Bivariate correlations were obtained through Pearson analysis. Results Phantom studies demonstrated that different concentrations of Cr exhibited significant CEST effect with the three sequences. The SNR obtained by sequences with and without ECG were both higher than that of base sequence (both P<0.05). Moreover,no significance of SNR was found between sequences with and without ECG (P>0.05). There were positive correlation of MTR between sequences with ECG,sequences without ECG and base protocol sequence (r2= 0.974 and 0.997, both P<0.05). Conclusion Compared with base protocol sequence, the optimized sequence with ECG can acquire higher SNR CrEST images,indicating that myocardial CrEST imaging could be performed in clinical practice.
