Quantitation of diffuse myocardial fibrosis using cardiac CT in heart failure: a pilot study
10.3760/cma.j.issn.1005?1201.2019.04.004
- VernacularTitle:心脏CT定量测量慢性心力衰竭患者细胞外容积的可行性研究
- Author:
Rui WANG
1
;
Xinmin LIU
;
Taiyang LUO
;
Ning YANG
;
Zhanming FAN
;
Lei XU
Author Information
1. 首都医科大学附属北京安贞医院医学影像科100029
- Keywords:
Heart failure;
Myocardial fibrosis;
Extracellular volume;
Tomography,X?ray computed;
Magnetic resonance imaging
- From:
Chinese Journal of Radiology
2019;53(4):256-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and accuracy of cardiac CT (CCT) in quantitation of extracellular volume (ECV) fraction in patients with heart failure, with 3 T Cardiac MR (CMR) as the reference. Methods Twenty?eight patients with variety reasons of heart failure were enrolled in this study. ECVs was calculated, the correlation between CCT and CMR ECV value and other cardiac function parameters (left ventricular end systolic volume LVESV, left ventricular end diastolic volume LVEDV, cardiac output CO and ejection fraction LVEF, and clinical bio?marker BNP) was determined. Interclass correlation coefficient (ICC) was used to evaluate the agreement of measurement by two radiologists. Results The average of ECV on CCT and CMR was 33% ± 8% and 31% ± 6%, respectively. A good correlation was revealed between myocardial ECV at CCT and that at CMR (r=0.854, P<0.001). Bland?Altman analysis between CCT and CMR showed a small bias (4.6%), with 95% limits of agreement of-18.2% to 27.4%. ICC for ECV at CCT was excellent (ICC=0.910). For both CCT and CMR, ECV was inversely related to LVEF. The radiation dose for CCT?ECV was (1.60±0.04) mSv. Conclusions ECV at CCT and that at CMR showed good correlation, suggesting the potential for myocardial tissue characterization using CCT. However, CCT?ECV would possibly overestimate the extent of ECV.
