Value of anti-Müllerian hormone and age in predicting pregnancy outcomes of in vitro fertilization and embryo transfer treatment
10.3760/cma.j.issn.0529-567x.2019.04.005
- VernacularTitle:抗苗勒管激素及年龄对体外受精-胚胎移植临床结局的预测价值
- Author:
Yuanhui CHEN
1
;
Qian WANG
;
Yanan ZHANG
;
Xiaohang XU
;
Jin LU
;
Shaodi ZHANG
;
Cuilian ZHANG
Author Information
1. 河南省人民医院生殖医学中心
- Keywords:
Anti-mullerian hormone;
Fertilization in vitro;
Embryo transfer;
Age factors;
Pregnancy outcome
- From:
Chinese Journal of Obstetrics and Gynecology
2019;54(4):239-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of anti-Müllerian hormone (AMH) and age in predicting outcomes of patients undergoing in vitro fertilization and embryo transfer treatment. Methods In this retrospective study, 6 328 Chinese patients who underwent the first in vitro fertilization or intracytoplasmic sperm injection and embryo transfer treatment in Henan Provincial People′s Hospital between July 2016 and July 2018 were analyzed. All the patients were categorized into two groups according to pregnancy or not. Baseline data and outcomes of two groups were compared. The regression analysis was conducted to identify the independent factors of clinical pregnancy rates. Furthermore, correlation analysis was performed between AMH and other factors. Results (1) The total clinical pregnancy rate was 56.86% (3 547/6 238). Age, AMH, basal FSH, antral follicle number (AFC), starting dose of gonadotropin (Gn), total doses of Gn, duration of Gn, number of oocytes, transferable cleavage embryos and transferred embryos were significantly different (all P<0.01). (2) Correlation analysis showed that AMH had significant passive correlation with age, basal FSH, starting dose of Gn and total doses of Gn (all P<0.01), while showed significant positive correlation with AFC, body mass index, duration of Gn, number of oocytes and transferable cleavage embryos (all P<0.01). Of all the factors, AMH had the strongest correlation with AFC (P<0.01). (3) Multivariate logistic regression analysis suggested that age was the independent influencing factor of clinical pregnancy rate ( OR=0.938, 95%CI : 0.824-0.952, P<0.01), while AMH not ( OR=1.004, 95%CI : 0.984-1.024, P=0.687). In the subgroups according to age, the advanced group (age>35 years old) had lower clinical pregnancy rate and higher cancellation rate for no available embryos. Conclusions AMH has no predictive value of clinical pregnancy outcomes for patients with in vitro fertilization and embryo transfer treatment, while age has certain predictive value of pregnancy outcomes. AMH level may have indictive value for the evaluation of ovarian reserve.
