Application of cross‐sectional area measurement under high frequency ultrasound in diagnosis of congenital adrenal hyperplasia in infants
10.3760/cma.j.issn.1004‐4477.2019.08.011
- VernacularTitle:高频超声下横截面积测量法在小婴儿先天性肾上腺皮质增生症诊断中的应用
- Author:
Zesheng YANG
1
;
Shicheng WANG
;
Guanghua PEI
;
Weijun XU
;
Xiaoying XIE
;
Shuo DONG
Author Information
1. 天津市儿童医院超声科300134
- Keywords:
Ultrasonography;
Congenital adrenal hyperplasia;
Infant;
Cross‐sectional area of adrenal gland
- From:
Chinese Journal of Ultrasonography
2019;28(8):700-703
- CountryChina
- Language:Chinese
-
Abstract:
To disscuss the role of cross‐sectional area measurement under high frequency ultrasound in the diagnosis of congenital adrenal hyperplasia ( CA H ) in infants . Methods T he abdominal ultrasound images of 20 infants with CA H w hich were admitted to our hospital and clinical diagnosised from November 2013 to August 2018 were analyzed retrospectively . T he size of adrenal glands were evaluated by measuring the maximum cross‐sectional area .Fifty normal full‐term infants were selected as control group synchronism . T he size of adrenal glands between infants with CA H and normal infants were compared . T he area under the curve ( AUC ) and best cutoff value were obtained by drawing ROC curve .Sensitivity and specificity were also obtained . Results T here was significant difference in maximum cross‐sectional area of adrenal gland between CA H group and control group[ ( 129 .70 ± 37 .34) mm2 vs ( 54 .41 ± 20 .84) mm2 , t ＝10 .004 , P ＝0 .001] . T he AUC of cross‐sectional area measurement was 0 .966 ,and best cutoff value was 87 .5 mm2 . T he sensitivity and specificity were 95 .0% and 92 .5% . Conclusions High‐frequency ultrasound is convenient and accurate in measuring the maximum cross‐sectional area of adrenal gland in infants . Cross‐sectional area measurement has high sensitivity and specificity to the diagnosis of CA H . T he presence of CA H is highly suspected w hen the area of adrenal gland reached 87 .5 mm2 .
