Effect of hepatogenous jaundice on liver stiffness measurement in patients with chronic hepatitis B
10.3760/cma.j.issn.1004‐4477.2019.08.007
- VernacularTitle:肝细胞性黄疸对慢性乙型肝炎患者剪切波肝杨氏模量值的影响
- Author:
Huanyi GUO
1
;
Mei LIAO
;
Ting ZHANG
;
Jie ZENG
;
Jieyang JIN
;
Rongqin ZHENG
Author Information
1. 中山大学附属第三医院超声科广东省肝脏疾病研究重点实验室
- Keywords:
Shear wave elastography;
Jaundice,hepatogenous;
Hepatitis B;
Elastic modulus
- From:
Chinese Journal of Ultrasonography
2019;28(8):680-684
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the impact of intrahepatic cholestasis on liver stiffness measurement ( LSM ) of two‐dimensional shear wave elastography ( 2D‐SWE ) in patients with chronic hepatitis B . Methods Between June 2011 and December 2016 , total of 1 188 patients with chronic hepatitis B infection were enrolled to collect clinical ,2D‐SWE ,biochemical variables and histological ( M ET AVIR scoring system ) datas . LSM was compared between normal total bilirubin group ( TB ＜ 23 .9 μmol/L ) versus abnormal TB group( ≥23 .9 μmol/L ) . Correlation of TB with LSM s was assessed . Results Nine hundred and seventy‐three patients with effective LSM in the study were analyzed . Within the same fibrosis stage ( F1‐F4) ,LSM showed significantly higher value in abnormal TB group than those of normal TB group ( r＝0 .328 ,0 .247 ,0 .495 ,0 .435 ,all P ＜ 0 .001 ) . Increased LSM for abnormal TB group was generally found within different subset of patients [ fibrosis stage ≤ F2 ,AL T ≥ 2 × upper limit of normal ( ULN ) ;fibrosis stage≤ F2 ,M ET AVIR activity grade ≤ A1 or ≥ A2 ] ,with r ＝ 0 .266 ,0 .210 ,0 .243 ( all P ＜0 .001) ,respectively .Increased LSM for abnormal TB group was also found within different subset of patients [ fibrosis stage≥F3 ,AL T＜2× ULN ,≥2×ULN ; fibrosis stage≥F3 ,M ET AVIR activity grade≥A2 ,with r ＝ 0 .671 ,0 .200 ,0 .468 ( all P ＜ 0 .05 ) ] . Conclusions Hepatogenous jaundice induced to intrahepatic cholestasis shows slight positive correlation with LSM s in patients with chronic hepatitis B .
