Optimization of Water Extraction and Alcohol Precipitation Process of Qizhi Yifei Granules by Multi-Index Orthogonal Experimental
10.3969/j.issn.1005-5304.2018.09.017
- VernacularTitle:多指标正交试验优化芪蛭益肺颗粒水提醇沉工艺
- Author:
Wen-Ping WANG
1
;
Jian NI
;
Xin LENG
;
Chun-Jing YANG
;
Long-Tai YOU
;
Yi LIU
;
Na SAI
;
Xiao LIANG
;
Xing-Bin YIN
Author Information
1. 北京中医药大学中药学院
- Keywords:
Qizhi Yifei Granules;
water extraction and alcohol precipitation;
astragaloside;
quercetin-3-O-β-D-glucose-7-O-β-D-gentian diglucoside
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(9):71-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction and alcohol precipitation process of Qizhi Yifei Granules by multi index orthogonal experiment. Methods With extraction rate of astragaloside in Astragali Radix, quercetin-3-O-β-D-glucose-7-O-β-D-gentian diglucoside in Descurainiae Semen Lepidii Semen and yield rate of dry extract as indexes, the extraction process of Qizhi Yifei Granules was optimized. Taking the retention rate of astragaloside and quercetin-3-O-β-D-glucose-7-O-β-D-gentian diglucoside as indexes, the alcohol precipitation process was optimized. Results The best water extraction process was as follows: adding 10 times amount of water, extracting for 1.5 h, 3 times. The optimum alcohol precipitation process was: concentrated to the relative density of 1.05–1.10 (60 ℃), adding ethanol to 60％ and alcohol precipitation. Conclusion The optimized extraction and alcohol precipitation process is stable and feasible, which can provide the basis for the preparation.
