Advances in relationship between Na+-Ca2+ exchanger protein and acute kidney injury

VernacularTitle:钠钙交换体与急性肾损伤的关系研究进展
Author: Weixiu WANG ¹ ; Sha CHEN ; Dingwei YANG
Author Information

1. 天津市天津医院肾内科
Keywords: Na+-Ca2+ exchanger; Acute kidney injury; Ischemia/reperfusion injury; Contrast-induced nephropathy
From: Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2019;26(2):251-253
CountryChina
Language:Chinese
Abstract: Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline of renal function in a short period of time. In recent years, the incidence of AKI has been increasing gradually. Once the AKI occurs in a patient whose mortality in hospital may be increased significantly, the length of stay in hospital will be prolonged and the hospitalization costs increased in a short term, the long-term consequences include AKI recurrence, development into chronic kidney disease (CKD) or end-stage kidney disease (ESRD), cardiovascular events and death, etc. Ischemia/reperfusion (I/R) injury and contrast agents are common causes of AKI. The nephropathy induced by I/R and contrast agent is associated with intracellular calcium overload caused by Na+-Ca2+ exchanger (NCX). In this article, a systematic review of the relationship between NCX and AKI was conducted, aiming to provide a reference for further recognizing the prevention, treatment and prognosis of AKI.