Research and application progress of circulating tumor cells in hepatocellular carcinoma
10.3969/j.issn.1000-8179.2019.13.686
- VernacularTitle:循环肿瘤细胞在肝癌中的研究及应用进展*
- Author:
Yijie HAO
1
;
Zheyu NIU
;
Jun LU
Author Information
1. 山东大学附属省立医院肝胆外科(济南市250012
- Keywords:
circulating tumor cells (CTCs);
hepatocellular carcinoma (HCC);
detection;
clinical application;
classification
- From:
Chinese Journal of Clinical Oncology
2019;46(13):690-693
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with high morbidity and mortality and poor prognosis. The main reason for poor prognosis are difficulties in early diagnosis, common recurrence and metastasis after surgery. Therefore, early diagnosis and postoperative monitoring of HCC are particularly important to improve the overall prognosis of HCC patients. Circulating tumor cells (CTCs) are malignant tumor cells in blood circulation, which play an important role in tumor inva-sion and metastasis. As a"liquid biopsy"technique, CTC test can be performed in real-time and allows repeated monitoring of tumor cells in peripheral blood, which has great clinical application value in early tumor diagnosis, postoperative dynamic monitoring, and prognosis evaluation. In this article, the research progress of CTCs at home and abroad was retrospectively illustrated, and their detec-tion methods, research, and clinical applications for diagnosis, prognosis, and other aspects of HCC patients were systematically re-viewed.
