The crosstalk between immunosenescence and tumor pathogenesis
10.3969/j.issn.1000-8179.2019.13.743
- VernacularTitle:免疫衰老与肿瘤发病机制*
- Author:
Wang YAO
1
;
Bin LUO
;
Jianhui TIAN
Author Information
1. 上海中医药大学附属龙华医院肿瘤科(上海市200032)
- Keywords:
immune system;
immunosenescence;
neoplasm;
pathogenesis
- From:
Chinese Journal of Clinical Oncology
2019;46(13):686-689
- CountryChina
- Language:Chinese
-
Abstract:
Immunosenescence is the decline in the structure and function of the body's immune system that involves organs, cells, im-mune factors, and regulatory networks. Decreased immunity and immune clearance, caused by immunosenescence, are key contribu-tors to tumorigenesis. This article begins by introducing the concept of immunosenescence and provides a comprehensive description of the relationship between immunosenescence and tumorigenesis. We also discuss the influence of the various components of the immune system on tumor incidence. Finally, the article provides ideas for immunosenescence intervention aimed at the prevention and treatment of cancer.
