Diagnosis and prognosis of adrenocortical carcinoma in children
10.3969/j.issn.1000-8179.2019.13.662
- VernacularTitle:儿童肾上腺皮质癌的诊断与预后
- Author:
Chenjun CHEN
1
;
Yunfei GUO
;
Geng MA
;
Zheng GE
;
Rugang LU
;
Yongji DENG
;
Lixia WANG
;
Jun DONG
Author Information
1. 南京医科大学附属儿童医院泌尿外科(南京市210008)
- Keywords:
adrenocortical carcinoma;
adrenalcortical adenoma;
diagnosis;
prognosis
- From:
Chinese Journal of Clinical Oncology
2019;46(13):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the diagnosis and prognosis of adrenocortical carcinoma in children. Methods: Medical records of 10 pediatric patients with adrenocortical cancer treated in Children's Hospital of Nanjing Medical University from September 2010 to March 2018 were retrospectively reviewed, and their clinical manifestation, laboratory, auxiliary, and pathological examination results, and prognosis were analyzed. Results: The average age of all patients (5 male and 5 female pediatric patients) was (53.3+48.4) months. Clinical mani-festations included abdominal mass, hypertension, cortisol level, and peripheral precocious puberty. Laboratory tests showed that lactate dehydrogenase, neuroenolase, and cortisol levels were high in some patients, and sex hormones were abnormal. Auxiliary examination using the abdominal computed tomography enhancement showed irregular an adrenal gland, uneven density, necrosis, mass calcification, and some infiltration into the surrounding tissue. Pathological examination suggests tumor cell pleomorphism, more frequent pathological division, high mitotic index, abundant interstitial sinusoid, necrosis, tumor infiltration, vascular invasion, and Weiss score of≥3 points. Lactate acid dehydrogenase and cortisol levels; Weiss score; and tumor size, staging, and resection rate were not statistically different among prognostic factors. Conclusions: For pediatric patients with adrenal masses, the survival rate should be improved by combining the clinical manifestation, laboratory examination, and auxiliary examination for the early diagnosis of adrenocortical carcinoma and to select the appropriate treatment. Combined with pathological results, adrenocortical carcinoma can be well differentiated from other adrenal masses.
