The function of long non-coding RNA in the occurrence and development of multiple myeloma
10.3969/j.issn.1000-8179.2019.12.236
- VernacularTitle:长链非编码RNA在多发性骨髓瘤发生发展中的作用*
- Author:
Yuqin HE
1
;
Wen GAO
;
Wenming CHEN
Author Information
1. 首都医科大学附属北京朝阳医院急诊科(北京市100020)
- Keywords:
malignancy;
multiple myeloma;
genetic heterogeneity;
long non-coding RNA (lncRNA)
- From:
Chinese Journal of Clinical Oncology
2019;46(12):640-644
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is characterized by genetic heterogeneity and is a common secondary hematological malignancy. Many studies have revealed that variation in the number of long non-coding RNAs (lncRNAs) is related to the degree of MM malignancy. Advances in molecular biology technologies, such as fluorescence in situ hybridization, high-throughput sequencing, gene microarrays, and qRT-PCR, have furthered research into cytogenetic malfunction in MM. Eleven newly discovered lncRNAs in MM have been fully interpreted according to the different mechanisms of MM and have the potential to be promising biomarkers for MM diagnosis and therapy.
