Retrospective analysis of clinical characteristics and prognostic factors of primary breast diffuse large B-cell lymphoma
10.3969/j.issn.1000-8179.2019.12.620
- VernacularTitle:62例原发性乳腺弥漫大B细胞淋巴瘤临床病例分析
- Author:
Jianing YI
1
;
Peizhi FAN
;
Zhou FAN
;
Pingyong YI
;
Shuai CHEN
;
Yang DU
Author Information
1. 湖南省人民医院乳甲外科(长沙市410002)
- Keywords:
breast neoplasm;
diffuse large B-cell lymphoma;
clinical characteristics;
prognosis
- From:
Chinese Journal of Clinical Oncology
2019;46(12):606-610
- CountryChina
- Language:Chinese
-
Abstract:
To study the clinical and pathological characteristics and prognostic factors of primary breast diffuse large B-cell lymphoma (PBDLBCL). Methods: Clinical and pathological data of 62 patients with PBDLBCL from January 2006 to December 2016 were retrospectively analyzed. The Kaplan-Meier method was used for univariate analysis and the Cox regression model for multivari-ate analysis. Results: The 62 patients analyzed included women aged 26-71 years, with a median age of 47 years. Patients were fol-lowed up from 6 to 105 months; the 3-year overall survival (OS) rate was 71.0%, and 5-year OS rate was 51.0%. The univariate analysis showed statistically significant differences in the clinical stage, lactic acid dehydrogenase level, International Prognostic Index score, Myc/Bcl-2 protein expression, and chemotherapy regimen at 3 and 5 years associated with OS rates. The multivariate analysis showed that Myc/Bcl-2 protein expression was an independent prognostic factor of OS. Conclusions: Comprehensive treatment with chemo-therapy and radiotherapy is appropriate for PBDLBCL. Myc/Bcl-2 protein expression is an independent adverse prognostic factor for PB-DLBCL.
