Advances in the relationship between gene mutation status and cancer-associated ve-nous thrombosis
10.3969/j.issn.1000-8179.2019.11.128
- VernacularTitle:基因突变状态与肿瘤相关性静脉血栓关系的研究进展
- Author:
Yapei ZHANG
1
;
Xue ZHANG
;
Da JIANG
Author Information
1. 河北医科大学第四医院肿瘤内科(石家庄市050011
- Keywords:
cancer;
venous thromboembolism;
gene;
relationship
- From:
Chinese Journal of Clinical Oncology
2019;46(11):589-594
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated venous thromboembolic disease (VTE) has become the second leading cause of death among cancer pa-tients. Some scholars have proposed a variety of thrombosis risk models to screen out patients with a higher thrombosis risk and then offer them drug or physical intervention measures to reduce the incidence of cancer-associated VTE. However, with the continuous de-velopment of precision medicine, these conclusions can no longer meet the requirements of medical personnel to explore the prob-lems of cancer-associated VTE. Genetic testing has become the "baseline" test in cancer patients. Common driver genes, such as the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), v-ros UR2 virus oncogene homolog 1 (ROS1), and kirsten ras sarcoma (KRAS), have become the normalcy and are recommended by the guidelines for clinical use. The status of gene mutations in clinical prognosis and treatment is increasingly prominent. This review discusses whether there is a correlation between cancer-as-sociated VTE and gene status and whether we can screen out cancer populations with a higher risk of thrombosis according to gene status, thus providing a theoretical basis for better implementation of prevention management strategies.
