Current status of synthetic lethality effects in cancer research
10.3969/j.issn.1000-8179.2019.10.356
- VernacularTitle:协同致死效应在肿瘤研究中的现状
- Author:
Dongming LIU
1
;
Hua GUO
Author Information
1. 天津医科大学肿瘤医院肿瘤细胞生物学实验室
- Keywords:
tumor;
mutation;
targeted therapy;
synthetic lethality effect
- From:
Chinese Journal of Clinical Oncology
2019;46(10):528-532
- CountryChina
- Language:Chinese
-
Abstract:
Most carcinogenic mutations, including those causing a loss of function, are not directly "druggable" with traditional small-molecule inhibitors, such as targeted drugs. Thus, despite our growing cognition of carcinogenic mutations that drive tumor progres-sion, there are still problems regarding targeted therapy for tumors. The application of synthetic lethality effects is expected to be-come a new breakthrough in tumor-targeted therapy. Therefore, identifying a combination of genetic mutations that generate synthet-ic lethality effects plays important roles in targeted therapy for tumors. This article reviews the origin and development of synthetic le-thality effects, the forms of interaction, related screening techniques, clinical treatment strategies, and significance and challenges.
