Research progress in mechanisms of tumor-associated neutrophils promoting tumor metastasis
10.3969/j.issn.1000-8179.2019.10.354
- VernacularTitle:肿瘤相关性中性粒细胞促肿瘤转移机制的研究进展
- Author:
Jiaqing LI
1
;
Qingying WANG
;
Zhongping CHENG
Author Information
1. 同济大学附属上海市第十人民医院妇产科(上海市200040
- Keywords:
tumor-associated neutrophils (TANs);
tumor;
metastasis;
mechanism
- From:
Chinese Journal of Clinical Oncology
2019;46(10):524-527
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophils are the most abundant leukocytes in the peripheral blood and play an important role in the immune response. However, there is growing evidence indicating that in addition to the immune response, neutrophils also have a crucial role in tumor development, especially in the process of invasion and metastasis. According to current research, depending on their phenotype, neu-trophils appear to be either anti-metastasis (N1) or pro-metastasis (N2). However, the role of tumor-associated neutrophils (TANs) in the metastasis of tumors is relatively complex and lacks a systematic introduction. This review mainly introduces TANs and focuses on the mechanism of TANs in promoting tumor invasion and metastasis. Finally, the possibility of TANs as an anti-tumor treatment strate-gy is discussed.
