Research progress and new ideas in circadian gene Bmal1 and oncotherapy
10.3969/j.issn.1000-8179.2019.10.366
- VernacularTitle:生物钟Bmal1基因与肿瘤治疗的研究进展及未来新思路
- Author:
Yue CHEN
1
,
2
;
Feng JIN
Author Information
1. 贵州医科大学(贵阳市550000)
2. 贵州医科大学附属肿瘤医院
- Keywords:
circadian rhythm;
Bmal1 gene;
tumor;
chrono-therapy
- From:
Chinese Journal of Clinical Oncology
2019;46(10):518-523
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm plays a role in regulating life activities and contributes to periodicity, orderliness, and synergy in organ-isms . The Bmal1 gene is one of the core components of the circadian rhythm system; the level of Bmal1 expression differs between tu-mor and normal tissues. Studies have shown that Bmal1 plays different roles in different tumors. Therefore, understanding the role of Bmal1 in different tumorigenesis could provide a new theoretical basis for early detection or effective treatment of tumors. In recent years, with the in-depth studies on time-based approaches, chrono-chemotherapy, which combines pharmacokinetics and biotic rhythm, has become one of the important methods of tumor treatment. Radiotherapy at different times can lead to differences in ra-diosensitivity, which makes chrono-radiotherapy increasingly prominent in tumor treatment. In-depth studies on circadian rhythm in cancer biology could provide new perspectives for tumor treatment.
