Advances in the application of iron oxide based magnetic nanoparticles in cancer ther-anostics
10.3969/j.issn.1000-8179.2019.08.339
- VernacularTitle:基于氧化铁的磁性纳米颗粒在肿瘤诊疗中的应用进展*
- Author:
Lufeng CHEN
1
;
Hongshan ZHONG
;
Ke XU
Author Information
1. 中国医科大学附属第一医院放射科
- Keywords:
magnetic nanoparticles;
iron oxide;
cancer;
theranostics;
multi-modality imaging
- From:
Chinese Journal of Clinical Oncology
2019;46(8):416-420
- CountryChina
- Language:Chinese
-
Abstract:
Cancer theranostics has attracted increasing attention in the area of nanooncology, where the therapeutic drugs and diag-nostic imaging are integrated into a multifunctional nanoplatform. A theranostic nanoparticle can deliver therapeutic drugs and imag-ing agents simultaneously. Iron oxide based magnetic nanoparticles (MNPs) are one of the most typical theranostic nanoparticles and have many excellent properties, such as biosafety, superparamagnetism, and tunable surface modifications and functionalizations. Moreover, they have drug loading capacity along with the distinctive properties of T2 weighted magnetic resonance imaging (T2W MRI), magnetic targeting, and magnetic hyperthermia. Presently, iron oxide based MNPs are being widely used in cancer theranostic research. This paper introduces the general structure of iron oxide based MNPs and reviews their applications in cancer dual/multiple modal imaging (T2W MRI combining T1W MRI, CT, optical imaging, PET/SPECT, and ultrasound) and therapy (chemotherapy, photody-namic therapy, photothermal therapy, and magnetic hyperthermia).
